Estrogen deficiency induces the differentiation of IL-17 secreting Th17 cells: a new candidate in the pathogenesis of osteoporosis.

M Tyagi, Abdul; Srivastava, Kamini; Nizam Mansoori, Mohd; Trivedi, Ritu; Chattopadhyay, Naibedya; Singh, Divya

doi:10.1371/journal.pone.0044552

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Estrogen deficiency induces the differentiation of IL-17 secreting Th17 cells: a new candidate in the pathogenesis of osteoporosis.

Shared by NobleBlocks on Jan 1, 2012 • 12:00 AM UTC

Authors:

Abdul M Tyagi

Kamini Srivastava

Mohd Nizam Mansoori

Abstract

Th17 cells produce IL-17, and the latter promotes bone loss in collagen-induced arthritis in mice. Blocking IL-17 action in mouse model of rheumatoid arthritis reduces disease symptoms. These observations suggest that Th17 cells may be involved in the pathogenesis of bone loss. However, the role of ...

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