Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

Shibata, H; Toyama, K; Shioya, H; Ito, M; Hirota, M; Hasegawa, S; Matsumoto, H; Takano, H; Akiyama, T; Toyoshima, K; Kanamaru, R; Kanegae, Y; Saito, I; Nakamura, Y; Shiba, K; Noda, T

doi:10.1126/science.278.5335.120

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Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

Shared by NobleBlocks on Oct 3, 1997 • 12:00 AM UTC

Authors:

H Shibata

K Toyama

H Shioya

Abstract

Familial adenomatous polyposis coli (FAP) is a disease characterized by the development of multiple colorectal adenomas, and affected individuals carry germline mutations in the APC gene. With the use of a conditional gene targeting system, a mouse model of FAP was created that circumvents the embry...

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