Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.

Saxena, Richa; Saleheen, Danish; F Been, Latonya; L Garavito, Martha; Braun, Timothy; Bjonnes, Andrew; Young, Robin; Kee Ho, Weang; Rasheed, Asif; Frossard, Philippe; Sim, Xueling; Hassanali, Neelam; Radha, Venkatesan; Chidambaram, Manickam; Liju, Samuel; D Rees, Simon; Peng-Keat Ng, Daniel; Wong, Tien-Yin; Yamauchi, Toshimasa; Hara, Kazuo; Tanaka, Yasushi; Hirose, Hiroshi; I McCarthy, Mark; P Morris, Andrew; , DIAGRAM; , MuTHER; , AGEN; Basit, Abdul; H Barnett, Anthony; Katulanda, Prasad; Matthews, David; Mohan, Viswanathan; S Wander, Gurpreet; Rup Singh, Jai; K Mehra, Narinder; Ralhan, Sarju; Ilyas Kamboh, M; J Mulvihill, John; Maegawa, Hiroshi; Tobe, Kazuyuki; Maeda, Shiro; S Cho, Yoon; Shyong Tai, E; Ann Kelly, M; C Chambers, John; S Kooner, Jaspal; Kadowaki, Takashi; Deloukas, Panos; J Rader, Daniel; Danesh, John

doi:10.2337/db12-1077

Public

Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.

Shared by NobleBlocks on May 1, 2013 • 12:00 AM UTC

Authors:

Richa Saxena

Danish Saleheen

Latonya F Been

Abstract

We performed a genome-wide association study (GWAS) and a multistage meta-analysis of type 2 diabetes (T2D) in Punjabi Sikhs from India. Our discovery GWAS in 1,616 individuals (842 case subjects) was followed by in silico replication of the top 513 independent single nucleotide polymorphisms (SNPs)...

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