Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein.

K, Yeung; P, Janosch; B, McFerran; DW, Rose; H, Mischak; JM, Sedivy; W, Kolch

doi:10.1128/mcb.20.9.3079-3085.2000

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Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein.

Published in Molecular and cellular biology • May 1, 2000

Authors:

Yeung K

Janosch P

McFerran B

Abstract

We have recently identified the Raf kinase inhibitor protein (RKIP) as a physiological endogenous inhibitor of the Raf-1/MEK/extracellular signal-regulated kinase (ERK) pathway. RKIP interfered with MEK phosphorylation and activation by Raf-1, resulting in the suppression of both Raf-1-induced trans...

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