LPS Sensitizes TRPV1 via Activation of TLR4 in Trigeminal Sensory Neurons

Diogenes, A.; Ferraz, C.C.R.; Akopian, A.N.; Henry, M.A.; Hargreaves, K.M.

doi:10.1177/0022034511400225

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LPS Sensitizes TRPV1 via Activation of TLR4 in Trigeminal Sensory Neurons

Shared by NobleBlocks on Mar 10, 2011 • 12:00 AM UTC

Authors:

A. Diogenes

C.C.R. Ferraz

A.N. Akopian

Abstract

Recent studies have demonstrated that the lipopolysaccharide (LPS) receptor (TLR4) is expressed in TRPV1 containing trigeminal sensory neurons. In this study, we evaluated whether LPS activates trigeminal neurons, and sensitizes TRPV1 responses via TLR4. To test this novel hypothesis, we first demon...

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