Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes.

Y, Tsuji; S, Zicha; XY, Qi; I, Kodama; S, Nattel

doi:10.1161/circulationaha.105.552968

Public

Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes.

Shared by NobleBlocks on Jan 1, 2006 • 12:00 AM UTC

Authors:

Tsuji Y

Zicha S

Qi XY

Abstract

<h4>Background</h4>Sustained heart rate abnormalities produce electrical remodeling and susceptibility to arrhythmia. Uncontrolled tachycardia produces heart failure and ventricular tachyarrhythmia susceptibility, whereas bradycardia promotes spontaneous torsade de pointes (TdP). This study compared...

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