Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression.

W Shen, D; G Lu, Y; V Chin, K; Pastan, I; M Gottesman, M

doi:10.1242/jcs.98.3.317

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Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression.

Shared by NobleBlocks on Mar 1, 1991 • 12:00 AM UTC

Authors:

D W Shen

Y G Lu

K V Chin

Abstract

Multidrug resistance of human cancer cells may result from expression of P-glycoprotein, the product of the MRD1 gene, acting as an energy-dependent drug efflux pump. However, direct evidence that expression of the MDR1 gene contributes to the multidrug resistance of human liver carcinomas has not b...

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