Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression.

H, Radziewicz; CC, Ibegbu; ML, Fernandez; KA, Workowski; K, Obideen; M, Wehbi; HL, Hanson; JP, Steinberg; D, Masopust; EJ, Wherry; JD, Altman; BT, Rouse; GJ, Freeman; R, Ahmed; A, Grakoui

doi:10.1128/jvi.02021-06

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Liver-infiltrating lymphocytes in chronic human hepatitis C virus infection display an exhausted phenotype with high levels of PD-1 and low levels of CD127 expression.

Shared by NobleBlocks on Dec 20, 2006 • 12:00 AM UTC

Authors:

Radziewicz H

Ibegbu CC

Fernandez ML

Abstract

The majority of people infected with hepatitis C virus (HCV) fail to generate or maintain a T-cell response effective for viral clearance. Evidence from murine chronic viral infections shows that expression of the coinhibitory molecule PD-1 predicts CD8+ antiviral T-cell exhaustion and may contribut...

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