Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.

Y, Nishizato; I, Ieiri; H, Suzuki; M, Kimura; K, Kawabata; T, Hirota; H, Takane; S, Irie; H, Kusuhara; Y, Urasaki; A, Urae; S, Higuchi; K, Otsubo; Y, Sugiyama

doi:10.1016/s0009-9236(03)00060-2

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Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics.

Shared by NobleBlocks on Jun 1, 2003 • 12:00 AM UTC

Authors:

Nishizato Y

Ieiri I

Suzuki H

Abstract

<h4>Objective</h4>Our objective was to quantitate the contribution of the genetic polymorphisms of the genes for 2 human organic anion transporters-organic anion transporting polypeptide C (OATP-C) and organic anion transporter 3 (OAT3)-to the pharmacokinetics of pravastatin.<h4>Methods</h4>Genetic ...

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