Copper-catalyzed tandem phosphination-decarboxylation-oxidation of alkynyl acids with H-phosphine oxides: a facile synthesis of β-ketophosphine oxides.

P, Zhang; L, Zhang; Y, Gao; J, Xu; H, Fang; G, Tang; Y, Zhao

doi:10.1039/c5cc01904d

Public

Copper-catalyzed tandem phosphination-decarboxylation-oxidation of alkynyl acids with H-phosphine oxides: a facile synthesis of β-ketophosphine oxides.

Shared by NobleBlocks on May 1, 2015 • 12:00 AM UTC

Authors:

Zhang P

Zhang L

Gao Y

Abstract

The general method for the tandem phosphination-decarboxylation-oxidation of alkynyl acids under aerobic conditions has been developed. In the presence of CuSO4·5H2O and TBHP, the reactions provide a novel access to β-ketophosphine oxides in good to excellent yields. This transformation allows the d...

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