Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury.

M, Tsuda; A, Mizokoshi; Y, Shigemoto-Mogami; S, Koizumi; K, Inoue

doi:10.1002/glia.10308

Public

Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury.

Shared by NobleBlocks on Jan 1, 2004 • 12:00 AM UTC

Authors:

Tsuda M

Mizokoshi A

Shigemoto-Mogami Y

Abstract

Neuropathic pain is an expression of pathological operation of the nervous system, which commonly results from nerve injury and is characterized by pain hypersensitivity to innocuous stimuli, a phenomenon known as tactile allodynia. The mechanisms by which nerve injury creates tactile allodynia have...

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