Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

Yasuda, Hisataka; Shima, Nobuyuki; Nakagawa, Nobuaki; Yamaguchi, Kyoji; Kinosaki, Masahiko; Mochizuki, Shin-ichi; Tomoyasu, Akihiro; Yano, Kazuki; Goto, Masaaki; Murakami, Akihiko; Tsuda, Eisuke; Morinaga, Tomonori; Higashio, Kanji; Udagawa, Nobuyuki; Takahashi, Naoyuki; Suda, Tatsuo

doi:10.1073/pnas.95.7.3597

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Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

Shared by NobleBlocks on Mar 28, 1998 • 12:00 AM UTC

Authors:

Hisataka Yasuda

Nobuyuki Shima

Nobuaki Nakagawa

Abstract

Osteoclasts, the multinucleated cells that resorb bone, develop from hematopoietic cells of monocyte/macrophage lineage. Osteoclast-like cells (OCLs) are formed by coculturing spleen cells with osteoblasts or bone marrow stromal cells in the presence of bone-resorbing factors. The cell-to-cell inter...

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