Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis.

R, Brenk; L, Naerum; U, Grädler; HD, Gerber; GA, Garcia; K, Reuter; MT, Stubbs; G, Klebe

doi:10.1021/jm0209937

Public

Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis.

Shared by NobleBlocks on Mar 1, 2003 • 12:00 AM UTC

Authors:

Brenk R

Naerum L

Grädler U

Abstract

Eubacterial tRNA-guanine transglycosylase (TGT) is involved in the hypermodification of cognate tRNAs, leading to the exchange of G34 by preQ1 at the wobble position in the anticodon loop. Mutation of the tgt gene in Shigella flexneri results in a significant loss of pathogenicity of the bacterium d...

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