Inhibition of histamine synthesis in brain by alpha-fluoromethylhistidine, a new irreversible inhibitor: in vitro and in vivo studies.

Garbarg, M; Barbin, G; Rodergas, E; C Schwartz, J

doi:10.1111/j.1471-4159.1980.tb07858.x

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Inhibition of histamine synthesis in brain by alpha-fluoromethylhistidine, a new irreversible inhibitor: in vitro and in vivo studies.

Published in Journal of neurochemistry • Nov 1, 1980

Authors:

M Garbarg

G Barbin

E Rodergas

Abstract

alpha-Fluoromethylhistidine (alpha-FMH), a new potent inhibitor of histidine decarboxylase (HD), has been used for in vitro and in vivo studies of brain HD. Following a preincubation with (+)-alpha-FMH, brain HD activity was inhibited in a time-dependent and concentration-dependent manner. The enzym...

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