Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) alpha or beta.

Okazaki, Ryo; Inoue, Daisuke; Shibata, Minako; Saika, Mieko; Kido, Shinsuke; Ooka, Hikari; Tomiyama, Hirofumi; Sakamoto, Yoshikazu; Matsumoto, Toshio

doi:10.1210/endo.143.6.8854

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Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) alpha or beta.

Shared by NobleBlocks on Jun 1, 2002 • 12:00 AM UTC

Authors:

Ryo Okazaki

Daisuke Inoue

Minako Shibata

Abstract

Although cells of the osteoblast lineage express functional ERs, direct effects of estrogen on bone formation remain obscure. In the present study, we have investigated estrogen effects on osteoblastic and adipocytic differentiation from a mouse bone marrow stromal cell line, ST-2, which had been ma...

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