Optimisation of the 10-23 DNAzyme-substrate pairing interactions enhanced RNA cleavage activity at purine-cytosine target sites.

MJ, Cairns; A, King; LQ, Sun

doi:10.1093/nar/gkg378

Public

Optimisation of the 10-23 DNAzyme-substrate pairing interactions enhanced RNA cleavage activity at purine-cytosine target sites.

Shared by NobleBlocks on Jun 1, 2003 • 12:00 AM UTC

Authors:

Cairns MJ

King A

Sun LQ

Abstract

The 10-23 RNA cleaving DNAzyme has been shown to cleave any purine-pyrimidine (RY) junction under simulated physiological conditions. In this study, we systematically examine the DNAzymes relative activity against different RY combinations in order to determine the hierarchy of substrate core dinucl...

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