Failure of parturition in mice lacking the prostaglandin F receptor.

Y, Sugimoto; A, Yamasaki; E, Segi; K, Tsuboi; Y, Aze; T, Nishimura; H, Oida; N, Yoshida; T, Tanaka; M, Katsuyama; K, Hasumoto; T, Murata; M, Hirata; F, Ushikubi; M, Negishi; A, Ichikawa; S, Narumiya

doi:10.1126/science.277.5326.681

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Failure of parturition in mice lacking the prostaglandin F receptor.

Shared by NobleBlocks on Aug 1, 1997 • 12:00 AM UTC

Authors:

Sugimoto Y

Yamasaki A

Segi E

Abstract

Mice lacking the gene encoding the receptor for prostaglandin F2alpha (FP) developed normally but were unable to deliver normal fetuses at term. Although these FP-deficient mice showed no abnormality in the estrous cycle, ovulation, fertilization, or implantation, they did not respond to exogenous o...

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