ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.

T, Stiff; M, O'Driscoll; N, Rief; K, Iwabuchi; M, Löbrich; PA, Jeggo

doi:10.1158/0008-5472.can-03-3207

Public

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.

Shared by NobleBlocks on Apr 1, 2004 • 12:00 AM UTC

Authors:

Stiff T

O'Driscoll M

Rief N

Abstract

H2AX phosphorylation is an early step in the response to DNA damage. It is widely accepted that ATM (ataxia telangiectasia mutated protein) phosphorylates H2AX in response to DNA double-strand breaks (DSBs). Whether DNA-dependent protein kinase (DNA-PK) plays any role in this response is unclear. He...

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