Effects of D-4F on vasodilation and vessel wall thickness in hypercholesterolemic LDL receptor-null and LDL receptor/apolipoprotein A-I double-knockout mice on Western diet.

J, Ou; J, Wang; H, Xu; Z, Ou; MG, Sorci-Thomas; DW, Jones; P, Signorino; JC, Densmore; S, Kaul; KT, Oldham; KA Jr, Pritchard

doi:10.1161/01.res.0000190634.60042.cb

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Effects of D-4F on vasodilation and vessel wall thickness in hypercholesterolemic LDL receptor-null and LDL receptor/apolipoprotein A-I double-knockout mice on Western diet.

Shared by NobleBlocks on Oct 13, 2005 • 12:00 AM UTC

Authors:

Ou J

Wang J

Xu H

Abstract

Previously we showed L-4F, a novel apolipoprotein A-I (apoA-I) mimetic, improved vasodilation in 2 dissimilar models of vascular disease: hypercholesterolemic LDL receptor-null (Ldlr(-/-)) mice and transgenic sickle cell disease mice. Here we determine the mechanisms by which D-4F improves vasodilat...

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