Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide.

JP, Lévesque; J, Hendy; Y, Takamatsu; PJ, Simmons; LJ, Bendall

doi:10.1172/jci15994

Public

Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide.

Shared by NobleBlocks on Jan 1, 2003 • 12:00 AM UTC

Authors:

Lévesque JP

Hendy J

Takamatsu Y

Abstract

Hematopoietic progenitor cells (HPCs) normally reside in the bone marrow (BM) but can be mobilized into the peripheral blood (PB) after treatment with GCSF or chemotherapy. In previous studies, we showed that granulocyte precursors accumulate in the BM during mobilization induced by either GCSF or c...

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