Essential Role of β-Catenin in Postnatal Bone Acquisition*

Holmen, S.; R. Zylstra, Cassandra; Mukherjee, A.; Sigler, R.; Faugere, M.; Bouxsein, M.; Deng, L.; Clemens, T.; Williams, B.

doi:10.1074/jbc.M501900200

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Essential role of beta-catenin in postnatal bone acquisition.

Shared by NobleBlocks on Mar 31, 2005 • 12:00 AM UTC

Authors:

Holmen SL

Zylstra CR

Mukherjee A

Abstract

Mutations in the Wnt co-receptor LRP5 alter bone mass in humans, but the mechanisms responsible for Wnts actions in bone are unclear. To investigate the role of the classical Wnt signaling pathway in osteogenesis, we generated mice lacking the beta-catenin or adenomatous polyposis coli (Apc) genes i...

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