Role of alpha(2)-macroglobulin in fever and cytokine responses induced by lipopolysaccharide in mice.

AV, Gourine; VN, Gourine; Y, Tesfaigzi; N, Caluwaerts; Leuven F, Van; MJ, Kluger

doi:10.1152/ajpregu.00746.2001

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Role of alpha(2)-macroglobulin in fever and cytokine responses induced by lipopolysaccharide in mice.

Shared by NobleBlocks on Jul 1, 2002 • 12:00 AM UTC

Authors:

Gourine AV

Gourine VN

Tesfaigzi Y

Abstract

Alpha(2)-macroglobulin (alpha(2)M) is not only a proteinase inhibitor in mammals, but it is also a specific cytokine carrier that binds pro- and anti-inflammatory cytokines implicated in fever, including interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha). To define the role of...

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