Akt/Protein kinase B modulates macrophage inflammatory response to Francisella infection and confers a survival advantage in mice.

MV, Rajaram; LP, Ganesan; KV, Parsa; JP, Butchar; JS, Gunn; S, Tridandapani

doi:10.4049/jimmunol.177.9.6317

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Akt/Protein kinase B modulates macrophage inflammatory response to Francisella infection and confers a survival advantage in mice.

Shared by NobleBlocks on Nov 1, 2006 • 12:00 AM UTC

Authors:

Rajaram MV

Ganesan LP

Parsa KV

Abstract

The Gram-negative bacterium Francisella novicida infects primarily monocytes/macrophages and is highly virulent in mice. Macrophages respond by producing inflammatory cytokines that confer immunity against the infection. However, the molecular details of host cell response to Francisella infection a...

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