Neonatal tolerization with glutamic acid decarboxylase but not with bovine serum albumin delays the onset of diabetes in NOD mice.

JS, Petersen; AE, Karlsen; H, Markholst; A, Worsaae; T, Dyrberg; B, Michelsen

doi:10.2337/diab.43.12.1478

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Neonatal tolerization with glutamic acid decarboxylase but not with bovine serum albumin delays the onset of diabetes in NOD mice.

Shared by NobleBlocks on Dec 1, 1994 • 12:00 AM UTC

Authors:

Petersen JS

Karlsen AE

Markholst H

Abstract

To test the role of glutamic acid decarboxylase (GAD65) or bovine serum albumin (BSA) autoimmunity in the pathogenesis of diabetes, GAD65 or BSA was injected intraperitoneally into neonatal female NOD mice (100 micrograms/mouse of each protein). Treatment with GAD65, but not with BSA, significantly ...

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