Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys.

E Bosinger, Steven; Li, Qingsheng; N Gordon, Shari; R Klatt, Nichole; Duan, Lijie; Xu, Luoling; Francella, Nicholas; Sidahmed, Abubaker; J Smith, Anthony; M Cramer, Elizabeth; Zeng, Ming; Masopust, David; V Carlis, John; Ran, Longsi; H Vanderford, Thomas; Paiardini, Mirko; Benjamin Isett, R; A Baldwin, Don; G Else, James; I Staprans, Silvija; Silvestri, Guido; T Haase, Ashley; J Kelvin, David

doi:10.1172/jci40115

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Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys.

Shared by NobleBlocks on Dec 1, 2009 • 12:00 AM UTC

Authors:

Steven E Bosinger

Qingsheng Li

Shari N Gordon

Abstract

Natural SIV infection of sooty mangabeys (SMs) is nonprogressive despite chronic virus replication. Strikingly, it is characterized by low levels of immune activation, while pathogenic SIV infection of rhesus macaques (RMs) is associated with chronic immune activation. To elucidate the mechanisms un...

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