Targeted gene silencing using RGD-labeled chitosan nanoparticles.

HD, Han; LS, Mangala; JW, Lee; MM, Shahzad; HS, Kim; D, Shen; EJ, Nam; EM, Mora; RL, Stone; C, Lu; SJ, Lee; JW, Roh; AM, Nick; G, Lopez-Berestein; AK, Sood

doi:10.1158/1078-0432.ccr-10-0005

Public

Targeted gene silencing using RGD-labeled chitosan nanoparticles.

Shared by NobleBlocks on Jun 10, 2010 • 12:00 AM UTC

Authors:

Han HD

Mangala LS

Lee JW

Abstract

<h4>Purpose</h4>This study aimed to develop an Arg-Gly-Asp (RGD) peptide-labeled chitosan nanoparticle (RGD-CH-NP) as a novel tumor targeted delivery system for short interfering RNA (siRNA).<h4>Experimental design</h4>RGD peptide conjugated with chitosan by thiolation reaction was confirmed by prot...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!