Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans.

Ogbonnaya Eleazu, Chinedum; Chinedum Eleazu, Kate; Chukwuma, Sonia; Nelson Essien, Udeme

doi:10.1186/2251-6581-12-60

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Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans.

Shared by NobleBlocks on Dec 23, 2013 • 12:00 AM UTC

Authors:

Chinedum Ogbonnaya Eleazu

Kate Chinedum Eleazu

Sonia Chukwuma

Abstract

Streptozotocin (STZ) (2-deoxy-2-({[methyl(nitroso)amino]carbonyl}amino)-β-D-glucopyranose) is a naturally occurring diabetogenic compound, produced by the soil bacterium streptomyces achromogenes, that exhibits broad spectrum of antibacterial properties. Streptozotocin functions as a DNA synthesis i...

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