Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin.

BF, Gage; C, Eby; JA, Johnson; E, Deych; MJ, Rieder; PM, Ridker; PE, Milligan; G, Grice; P, Lenzini; AE, Rettie; CL, Aquilante; L, Grosso; S, Marsh; T, Langaee; LE, Farnett; D, Voora; DL, Veenstra; RJ, Glynn; A, Barrett; HL, McLeod

doi:10.1038/clpt.2008.10

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Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin.

Shared by NobleBlocks on Feb 27, 2008 • 12:00 AM UTC

Authors:

Gage BF

Eby C

Johnson JA

Abstract

Initiation of warfarin therapy using trial-and-error dosing is problematic. Our goal was to develop and validate a pharmacogenetic algorithm. In the derivation cohort of 1,015 participants, the independent predictors of therapeutic dose were: VKORC1 polymorphism -1639/3673 G>A (-28% per allele), bod...

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