Ovarian carcinoma in situ with germline BRCA1 mutation and loss of heterozygosity at BRCA1 and TP53.

Werness, B.; Parvatiyar, Pankhuri; Ramus, S.; Whittemore, A.; Garlinghouse-Jones, Kim; Oakley-Girvan, Ingrid; Dicioccio, R.; S. Wiest, Jonathan; Tsukada, Yoshiaki; Ponder, B.; Piver, M.

doi:10.1093/JNCI/92.13.1088

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Ovarian carcinoma in situ with germline BRCA1 mutation and loss of heterozygosity at BRCA1 and TP53.

Shared by NobleBlocks on Jul 1, 2000 • 12:00 AM UTC

Authors:

Werness BA

Parvatiyar P

Ramus SJ

Abstract

Background The two-hit hypothesis for the genesis of cancer predicts that cancer can develop when the wild-type allele of a tumor suppressor gene is lost in an individual with a germline mutation in that gene. Neither loss of heterozygosity (LOH) for BRCA1 nor mutations of the TP53 (also known as p5...

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