Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using coumarinic acid and phenylpropionic acid linkers.

B, Wang; K, Nimkar; W, Wang; H, Zhang; D, Shan; O, Gudmundsson; S, Gangwar; T, Siahaan; RT, Borchardt

doi:10.1034/j.1399-3011.1999.00071.x

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Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using coumarinic acid and phenylpropionic acid linkers.

Shared by NobleBlocks on Apr 1, 1999 • 12:00 AM UTC

Authors:

Wang B

Nimkar K

Wang W

Abstract

In an attempt to improve the membrane permeabilities of opioid peptides, we have synthesized cyclic prodrugs of [Leu5]-enkephalin and DADLE using a coumarinic acid or a phenylpropionic acid linker. The synthesis of the coumarinic acid- and phenylpropionic acid-based cyclic prodrugs followed similar ...

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