An antibody-deficiency syndrome due to mutations in the CD19 gene.

<h4>Background</h4>The CD19 protein forms a complex with CD21, CD81, and CD225 in the membrane of mature B cells. Together with the B-cell antigen receptor, this complex signals the B cell to decrease its threshold for activation by the antigen.<h4>Methods</h4>We evaluated four patients from two unr... View More