Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines.

H, Kamihata; H, Matsubara; T, Nishiue; S, Fujiyama; Y, Tsutsumi; R, Ozono; H, Masaki; Y, Mori; O, Iba; E, Tateishi; A, Kosaki; S, Shintani; T, Murohara; T, Imaizumi; T, Iwasaka

doi:10.1161/hc3501.093817

Public

Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines.

Shared by NobleBlocks on Aug 1, 2001 • 12:00 AM UTC

Authors:

Kamihata H

Matsubara H

Nishiue T

Abstract

<h4>Background</h4>Bone marrow implantation (BMI) was shown to enhance angiogenesis in a rat ischemic heart model. This preclinical study using a swine model was designed to test the safety and therapeutic effectiveness of BMI.<h4>Methods and results</h4>BM-derived mononuclear cells (BM-MNCs) were i...

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