Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients.

FS, Hodi; M, Butler; DA, Oble; MV, Seiden; FG, Haluska; A, Kruse; S, Macrae; M, Nelson; C, Canning; I, Lowy; A, Korman; D, Lautz; S, Russell; MT, Jaklitsch; N, Ramaiya; TC, Chen; D, Neuberg; JP, Allison; MC, Mihm; G, Dranoff

doi:10.1073/pnas.0712237105

Public

Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients.

Shared by NobleBlocks on Feb 19, 2008 • 12:00 AM UTC

Authors:

Hodi FS

Butler M

Oble DA

Abstract

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) functions as a negative regulator of endogenous and vaccine-induced antitumor immunity. The administration of fully human anti-CTLA-4 blocking monoclonal antibodies to advanced-cancer patients increases immune-mediated tumor destruction in some su...

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