Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues

L. Scheller, Erica; R. Doucette, Casey; S. Learman, Brian; P. Cawthorn, William; Khandaker, Shaima; Schell, Benjamin; Wu, Brent; Ding, Shi-Ying; A. Bredella, Miriam; K. Fazeli, Pouneh; Khoury, Basma; J. Jepsen, Karl; F. Pilch, Paul; Klibanski, Anne; J. Rosen, Clifford; A. MacDougald, Ormond

doi:10.1038/ncomms8808

Public

Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues

Shared by NobleBlocks on Aug 6, 2015 • 12:00 AM UTC

Authors:

Erica L. Scheller

Casey R. Doucette

Brian S. Learman

Abstract

Abstract Marrow adipose tissue (MAT) accumulates in diverse clinical conditions but remains poorly understood. Here we show region-specific variation in MAT adipocyte development, regulation, size, lipid composition, gene expression and genetic determinants. Early MAT formation in mice is conserved,...

Discussions