An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis.

H, Furumoto; H, Ying; GV, Chandramouli; L, Zhao; RL, Walker; PS, Meltzer; MC, Willingham; SY, Cheng

doi:10.1128/mcb.25.1.124-135.2005

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An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis.

Shared by NobleBlocks on Jan 1, 2005 • 12:00 AM UTC

Authors:

Furumoto H

Ying H

Chandramouli GV

Abstract

Thyroid-stimulating hormone (TSH)-secreting tumors (TSH-omas) are pituitary tumors that constitutively secrete TSH. The molecular genetics underlying this abnormality are not known. We discovered that a knock-in mouse harboring a mutated thyroid hormone receptor (TR) beta (PV; TRbeta(PV/PV) mouse) s...

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