VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors

Voron, Thibault; Colussi, Orianne; Marcheteau, Elie; Pernot, Simon; Nizard, Mevyn; Pointet, Anne-Laure; Latreche, Sabrina; Bergaya, Sonia; Benhamouda, Nadine; Tanchot, Corinne; Stockmann, Christian; Combe, Pierre; Berger, Anne; Zinzindohoue, Franck; Yagita, Hideo; Tartour, Eric; Taieb, Julien; Terme, Magali

doi:10.1084/jem.20140559

Public

VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors

Shared by NobleBlocks on Jan 19, 2015 • 12:00 AM UTC

Authors:

Thibault Voron

Orianne Colussi

Elie Marcheteau

Abstract

Immune escape is a prerequisite for tumor development. To avoid the immune system, tumors develop different mechanisms, including T cell exhaustion, which is characterized by expression of immune inhibitory receptors, such as PD-1, CTLA-4, Tim-3, and a progressive loss of function. The recent develo...

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