Interferon-alpha2a and 13-cis-retinoic acid with radiation treatment for high-grade glioma.

RO, Dillman; WM, Shea; DF, Tai; K, Mahdavi; NM, Barth; BR, Kharkar; MM, Poor; CK, Church; C, DePriest

doi:10.1093/neuonc/3.1.35

Public

Interferon-alpha2a and 13-cis-retinoic acid with radiation treatment for high-grade glioma.

Shared by NobleBlocks on Jan 1, 2001 • 12:00 AM UTC

Authors:

Dillman RO

Shea WM

Tai DF

Abstract

Interferon-alpha (IFN-alpha) has been safely given concurrently with radiation therapy (RT) in treating gliomas. As single agents, both IFN-alpha and cis-retinoic acid (CRA) have produced objective tumor regressions in patients with recurrent gliomas. In vitro, IFN-alpha2a and CRA enhance radiation ...

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