Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.

H, Matsuo; T, Takada; K, Ichida; T, Nakamura; A, Nakayama; Y, Ikebuchi; K, Ito; Y, Kusanagi; T, Chiba; S, Tadokoro; Y, Takada; Y, Oikawa; H, Inoue; K, Suzuki; R, Okada; J, Nishiyama; H, Domoto; S, Watanabe; M, Fujita; Y, Morimoto; M, Naito; K, Nishio; A, Hishida; K, Wakai; Y, Asai; K, Niwa; K, Kamakura; S, Nonoyama; Y, Sakurai; T, Hosoya; Y, Kanai; H, Suzuki; N, Hamajima; N, Shinomiya

doi:10.1126/scitranslmed.3000237

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Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.

Shared by NobleBlocks on Nov 1, 2009 • 12:00 AM UTC

Authors:

Matsuo H

Takada T

Ichida K

Abstract

Gout based on hyperuricemia is a common disease with a genetic predisposition, which causes acute arthritis. The ABCG2/BCRP gene, located in a gout-susceptibility locus on chromosome 4q, has been identified by recent genome-wide association studies of serum uric acid concentrations and gout. Urate t...

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