Next-Generation Sequencing of Pulmonary Sarcomatoid Carcinoma Reveals High Frequency of Actionable MET Gene Mutations.

X, Liu; Y, Jia; MB, Stoopler; Y, Shen; H, Cheng; J, Chen; M, Mansukhani; S, Koul; B, Halmos; AC, Borczuk

doi:10.1200/jco.2015.62.0674

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Next-Generation Sequencing of Pulmonary Sarcomatoid Carcinoma Reveals High Frequency of Actionable MET Gene Mutations.

Shared by NobleBlocks on Jul 27, 2015 • 12:00 AM UTC

Authors:

Liu X

Jia Y

Stoopler MB

Abstract

<h4>Purpose</h4>To further understand the molecular pathogenesis of pulmonary sarcomatoid carcinoma (PSC) and develop new therapeutic strategies in this treatment-refractory disease.<h4>Materials and methods</h4>Whole-exome sequencing in a discovery set (n = 10) as well as targeted MET mutation scre...

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