Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens.

R, Freynhagen; K, Strojek; T, Griesing; E, Whalen; M, Balkenohl

doi:10.1016/j.pain.2005.02.032

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Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens.

Shared by NobleBlocks on Apr 18, 2005 • 12:00 AM UTC

Authors:

Freynhagen R

Strojek K

Griesing T

Abstract

Pregabalin binds with high affinity to the alpha2-delta subunit protein of voltage-gated calcium channels and, thereby, reduces release of excitatory neurotransmitters. This 12-week randomised, double-blind, multicentre, placebo-controlled, parallel-group study evaluated the efficacy and safety of p...

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