Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides.

KJ, Aichberger; M, Mayerhofer; MT, Krauth; H, Skvara; S, Florian; K, Sonneck; C, Akgul; S, Derdak; WF, Pickl; V, Wacheck; E, Selzer; BP, Monia; R, Moriggl; P, Valent; C, Sillaber

doi:10.1182/blood-2004-02-0749

Public

Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides.

Shared by NobleBlocks on Dec 30, 2004 • 12:00 AM UTC

Authors:

Aichberger KJ

Mayerhofer M

Krauth MT

Abstract

Antiapoptotic members of the bcl-2 family have recently been implicated in the pathogenesis of chronic myeloid leukemia (CML), a hematopoietic neoplasm associated with the BCR/ABL oncogene. We have examined expression of MCL-1 in primary CML cells and BCR/ABL-transformed cell lines. Independent of t...

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