Aerosolized Liposomal Amphotericin B for the Prevention of Invasive Pulmonary Aspergillosis during Prolonged Neutropenia: A Randomized, Placebo‐Controlled Trial

Rijnders, Bart; J. Cornelissen, Jan; Slobbe, Lennert; Becker, Martin; K. Doorduijn, Jeanette; C.J. Hop, Wim; J. Ruijgrok, Elisabeth; Löwenberg, Bob; G. Vulto, Arnold; J. Lugtenburg, Pieternella; de Marie, Siem

doi:10.1086/586739

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Aerosolized Liposomal Amphotericin B for the Prevention of Invasive Pulmonary Aspergillosis during Prolonged Neutropenia: A Randomized, Placebo‐Controlled Trial

Published in Clinical Infectious Diseases • Mar 24, 2008

Authors:

Bart Rijnders

Jan J. Cornelissen

Lennert Slobbe

Abstract

BACKGROUND: Invasive pulmonary aspergillosis (IPA) is a significant problem in patients with chemotherapy-induced prolonged neutropenia. Because pulmonary deposition of conidia is the first step in developing IPA, we hypothesized that inhalation of liposomal amphotericin B would prevent IPA. METHODS...

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Open Access

Subject

Medicine

Neutropenia

Amphotericin B

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