Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS

L. Ferrante, Kimberly; M. Shefner, Jeremy; Zhang, H.; A. Betensky, Rebecca; O’Brien, Mike; Yu, Hailing; A. Fantasia, Martha; Taft, J; Flint Beal, M.; Traynor, Bryan; Newhall, Kristyn; D. Donofrio, P.; B. Caress, James; Ashburn, C.; Loggan Freiberg, Barbara; J. O’Neill, Christine; Paladenech, Connie; Walker, Tracey; Pestronk, Alan; Abrams, Berenice; Florence, J.; Renna, Renee; Schierbecker, Jeanine; Malkus, Betsy; Cudkowicz, Merit

doi:10.1212/01.wnl.0000187070.35365.d7

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Tolerance of high-dose (3,000 mg/day) coenzyme Q10 in ALS

Published in Neurology • Dec 13, 2005

Authors:

Kimberly L. Ferrante

Jeremy M. Shefner

H. Zhang

Abstract

An open-label dose-escalation trial was performed to assess the safety and tolerability of high doses of coenzyme Q10 (CoQ10) in ALS. CoQ10, a cofactor in mitochondrial electron transfer, may improve the mitochondrial dysfunction in ALS. In this study, CoQ10 was safe and well tolerated in 31 subject...

Subject

Coenzyme Q10

Tolerability

Medicine

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