Randomized Double-Blind Assessment of the ONSET and OFFSET of the Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Stable Coronary Artery Disease

A. Gurbel, Paul; P. Bliden, Kevin; Butler, Kathleen; S. Tantry, Udaya; Gesheff, Tania; Wei, Cheryl; Teng, Renli; J. Antonino, Mark; B. Patil, Shankar; Karunakaran, Arun; J. Kereiakes, Dean; Parris, Cordel; Purdy, Drew; Wilson, Vance; S. Ledley, Gary; F. Storey, Robert

doi:10.1161/circulationaha.109.912550

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Randomized Double-Blind Assessment of the ONSET and OFFSET of the Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Stable Coronary Artery Disease

Shared by NobleBlocks on Dec 22, 2009 • 12:00 AM UTC

Authors:

Paul A. Gurbel

Kevin P. Bliden

Kathleen Butler

Abstract

Background— Ticagrelor is the first reversibly binding oral P2Y 12 receptor antagonist. This is the first study to compare the onset and offset of platelet inhibition (IPA) with ticagrelor using the PLATO (PLATelet inhibition and patient Outcomes) trial loading dose (180 mg) with a high loading dose...

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