EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

Paez, J.; Jänne, P.; C. Lee, Jeffrey; I Tracy, Sean; Greulich, H.; Gabriel, S.; Herman, P.; Kaye, F.; Lindeman, N.; Boggon, T.; Naoki, K.; Sasaki, H.; Fujii, Y.; Eck, M.; Sellers, W.; Johnson, B.; Meyerson, M.

doi:10.1126/SCIENCE.1099314

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EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

Shared by NobleBlocks on Jun 4, 2004 • 12:00 AM UTC

Authors:

J. Guillermo Paez

Pasi A. Jänne

Jeffrey C. Lee

Abstract

Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene EGFR were found in 15of 58 unselected tumors from Japan and 1 of 61 from the United States. Treatment with the EGFR kinase inh...

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