Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.

K, Kaibuchi; S, Kuroda; M, Amano

doi:10.1146/annurev.biochem.68.1.459

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Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.

Published in Annual review of biochemistry • Jan 1, 1999

Authors:

Kaibuchi K

Kuroda S

Amano M

Abstract

Members of the Rho family of small Ras-like GTPases--including RhoA, -B, and -C, Rac1 and -2, and Cdc42--exhibit guanine nucleotide-binding activity and function as molecular switches, cycling between an inactive GDP-bound state and an active GTP-bound state. The Rho family GTPases participate in re...

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