MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma.

Zhang, Chun-Zhi; Zhang, Jun-Xia; Zhang, An-Ling; Shi, Zhen-Dong; Han, Lei; Jia, Zhi-Fan; Yang, Wei-Dong; Wang, Guang-Xiu; Jiang, Tao; You, Yong-Ping; Pu, Pei-Yu; Cheng, Jin-Quan; Kang, Chun-Sheng

doi:10.1186/1476-4598-9-229

Public

MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma.

Shared by NobleBlocks on Sep 2, 2010 • 12:00 AM UTC

Authors:

Chun-Zhi Zhang

Jun-Xia Zhang

An-Ling Zhang

Abstract

BACKGROUND: MiR-221 and miR-222 (miR-221/222) are frequently up-regulated in various types of human malignancy including glioblastoma. Recent studies have reported that miR-221/222 regulate cell growth and cell cycle progression by targeting p27 and p57. However the underlying mechanism involved in ...

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