Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.

Zhang, Z.; Schuler, T.; Zupancic, M.; Wietgrefe, S.; Staskus, K.; Reimann, K.; Reinhart, T.; Rogan, M.; Cavert, W.; Miller, C.; Veazey, R.; Notermans, D.; Little, S.; Danner, S.; Richman, D.; Havlir, D.; Wong, J.; L. Jordan, H.; Schacker, T.; Rácz, P.; Tenner‐Racz, K.; Letvin, N.; Wolinsky, Steven; Haase, A.

doi:10.1126/SCIENCE.286.5443.1353

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Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4 + T Cells

Shared by NobleBlocks on Nov 12, 1999 • 12:00 AM UTC

Authors:

Z.-Q. Zhang

T. Schuler

M. Zupancic

Abstract

In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus–type 1 (HIV-1) infection, both viruses were found to replicate predominantly in CD4 + T cells at the portal of entry and in lymphoid tissues. Infection was propagated not only in activ...

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