The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors.

AA, Steiner; AY, Molchanova; MD, Dogan; S, Patel; E, Pétervári; M, Balaskó; SP, Wanner; J, Eales; DL, Oliveira; NR, Gavva; MC, Almeida; M, Székely; AA, Romanovsky

doi:10.1113/jphysiol.2010.202465

Public

The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors.

Shared by NobleBlocks on Mar 14, 2011 • 12:00 AM UTC

Authors:

Steiner AA

Molchanova AY

Dogan MD

Abstract

Hypothermia occurs in the most severe cases of systemic inflammation, but the mechanisms involved are poorly understood. This study evaluated whether the hypothermic response to bacterial lipopolysaccharide (LPS) is modulated by the endocannabinoid anandamide(AEA) and its receptors: cannabinoid-1 (C...

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