Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease.

G, Basurto-Islas; J, Luna-Muñoz; AL, Guillozet-Bongaarts; LI, Binder; R, Mena; F, García-Sierra

doi:10.1097/nen.0b013e31817275c7

Public

Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease.

Shared by NobleBlocks on May 1, 2008 • 12:00 AM UTC

Authors:

Basurto-Islas G

Luna-Muñoz J

Guillozet-Bongaarts AL

Abstract

Truncations of tau protein at aspartic acid421 (D421) and glutamic acid391 (E391) residues are associated with neurofibrillary tangles (NFTs) in the brains of Alzheimer disease (AD) patients. Using immunohistochemistry with antibodies to D421- and E391-truncated tau (Tau-C3 and MN423, respectively),...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!